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Publication Detail
Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1
  • Publication Type:
    Journal article
  • Publication Sub Type:
    JOUR
  • Authors:
    Effertz T, Nadrowski B, Piepenbrock D, Albert JT, Gopfert MC
  • Publication date:
    2012
  • Pagination:
    1198, 1200
  • Journal:
    Nature neuroscience
  • Volume:
    15
  • Medium:
    9
  • Print ISSN:
    1546-1726
  • Notes:
    Times Cited: 0 The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.
Abstract
The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.
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