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Publication Detail
Nuclear location signals in polyoma virus large-T
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Richardson WD, Roberts BL, Smith AE
  • Publication date:
  • Pagination:
    77, 85
  • Journal:
  • Volume:
  • Issue:
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  • Print ISSN:
We have found two mutually independent sequence elements that contribute to the nuclear location of polyoma virus large-T. The first sequence (pro lys lys282 ala arg glu asp) resembles the SV40 large-T nuclear signal (pro lys lys128 lys arg lys val) and occurs at a corresponding position within polyoma large-T. The second sequence (val ser arg lys192 arg pro arg) may be structurally related to the SV40 signal, although it has little sequence homology and falls in a region of the protein that has no counterpart in SV40 large-T. The data suggest that nuclear location signals with characteristics similar to the SV40 large-T prototype may be a more general feature of nuclear proteins, and that several such signals in a given protein can exert cooperative effects. © 1986.
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