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Publication Detail
Sequence requirements for nuclear location of simian virus 40 large-T antigen
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Kalderon D, Richardson WD, Markham AF, Smith AE
  • Publication date:
    01/12/1984
  • Pagination:
    33, 38
  • Journal:
    Nature
  • Volume:
    311
  • Issue:
    5981
  • Status:
    Published
  • Print ISSN:
    0028-0836
Abstract
A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys- 128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear location. © 1984 Nature Publishing Group.
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