Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Bilirubin does not modulate ionotropic glutamate receptors or glutamate transporters
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Warr O, Mort D, Attwell D
  • Publication date:
  • Pagination:
    13, 16
  • Journal:
    Brain Research
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    Alzheimer's disease, AMPA receptors, bilirubin, Blood, Brain, Carbon Monoxide, cell, CELLS, disease, glial cells, glutamate, jaundice, metabolism, neonatal, neuron, neurons, physiology, pyramidal cell, Receptor, synthesis, transporters, uptake
  • Addresses:
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, UK
Bilirubin, a product of haemoglobin metabolism, has been suggested to damage neurons by increasing activation of N-methyl-D-aspartate (NMDA) receptors when it reaches high levels in the blood [15,19], as occurs in neonatal jaundice [7]. Bilirubin is also generated in the brain following synthesis of the messenger carbon monoxide (CO) by haem oxygenase, and haem oxygenase is upregulated in Alzheimer's disease [23]. We examined the effect of bilirubin on currents generated by NMDA and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors in hippocampal pyramidal cells, and on glutamate transporter currents in retinal glial cells. Bilirubin did not modulate either receptor-gated currents or transporter currents. These data show the negative, but important result that bilirubin does not induce neuronal death by acting directly on NMDA or AMPA receptors, nor indirectly by blocking glutamate uptake and raising the extracellular concentration of glutamate
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Neuro, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by