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Publication Detail
Opioid modulation of GABA release in the rat inferior colliculus.
Abstract
Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information. While the majority of therecorded activities in the inferior colliculus are attributed to GABAergic and glutamatergicsignalling, other neurotransmitter systems are expressed in this brain area including opiate peptidesand their receptors which may play a modulatory role in neuronal communication.Results: Using a perfusion protocol we demonstrate that morphine can inhibit KCl-inducedrelease of [3H]GABA from rat inferior colliculus slices. DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin) but not DADLE ([D-Ala2, D-Leu5]-enkephalin or U69593 has the same effect asmorphine indicating that ? rather than ? or ? opioid receptors mediate this action. [3H]GABArelease was diminished by 16%, and this was not altered by the protein kinase C inhibitorbisindolylmaleimide I. Immunostaining of inferior colliculus cryosections shows extensive stainingfor glutamic acid decarboxylase, more limited staining for ? opiate receptors and relatively fewneurons co-stained for both proteins.Conclusion: The results suggest that ?-opioid receptor ligands can modify neurotransmitterrelease in a sub population of GABAergic neurons of the inferior colliculus. This could haveimportant physiological implications in the processing of hearing information and/or other functionsattributed to the inferior colliculus such as audiogenic seizures and aversive behaviour.
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