Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal cell proliferation
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Pearson RA, Dale N, Llaudet E, Mobbs P
  • Publication date:
  • Pagination:
    731, 744
  • Journal:
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    A, AND, ARTICLE, ATP, BOTH, cell, Cell Division, CELLS, connexin, development, DNA, Epithelium, identify, IM, INCREASE, IS, JOURNAL, LA, LONDON, Mechanism, MECHANISMS, MEMBRANE, OF, PHYSIOLOGY, PROLIFERATION, RECEPTOR, receptors, regulation, RELEASE, Retina, SYNTHESIS, THE, UNITED-KINGDOM, Unknown
  • Addresses:
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
  • Notes:
    DA - 20050531 IS - 0896-6273 LA - eng PT - Journal Article SB - IM
The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca(2+) transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate DNA synthesis in neural retinal progenitor cells. Here, we show that the RPE regulates proliferation in the underlying neural retina by the release of a soluble factor and identify that factor as ATP. Further, we show that this ATP is released by efflux through gap junction connexin 43 hemichannels, the opening of which is evoked by spontaneous elevations of Ca(2+) in trigger cells in the RPE. This release mechanism is localized within the RPE cells to the membranes facing the neural retina, a location ideally positioned to influence neural retinal development. ATP released from RPE hemichannels speeds both cell division and proliferation in the neural retina
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Div of Biosciences
Institute of Ophthalmology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by