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Publication Detail
Hyperinsulinism in infancy: from basic science to clinical disease
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Dunne MJ, Cosgrove KE, Shepherd RM, Aynsley-Green A, Lindley KJ
  • Publication date:
  • Pagination:
    239, 275
  • Journal:
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    A, ALL, AND, animals, ARTICLE, BETA-CELL, cell, CELLS, Channel, CHANNELS, CHEMISTRY, CHILDHOOD, CLINICAL, Condition, cytology, DEFECT, DEFECTS, Diabetes, DISEASE, Disease Models, Animal, DISORDER, DISORDERS, drug therapy, ENDOCRINE, ENDOCRINE PANCREAS, enzyme, Enzymes, EPITHELIAL CELLS, EPITHELIAL-CELLS, FOR, FUNCTION, GENE, genetics, Glucose, HUMANS, hyperinsulinism, IM, INFANCY, Infant, Newborn, INSULIN, Ion Channels, ION TRANSPORT, IS, Islets of Langerhans, JOURNAL, LA, medicine, metabolic, METABOLISM, MOLECULAR, Myocytes, Neuron, NEURONS, NEWBORN, OF, Pancreas, PATHOGENESIS, Pathology, PATHWAY, Persistent Hyperinsulinemia Hypoglycemia of Infancy, pharmacology, PHYSIOLOGY, physiopathology, Potassium, POTASSIUM CHANNEL, Potassium Channels, PROTEIN, relationship, RELEASE, Research, Research Support, Non-U.S.Gov't, REVIEW, THE, TRANSPORT, UNITED-KINGDOM
  • Addresses:
    Research Division of Physiology and Pharmacology, The School of Biological Sciences, University of Manchester, Manchester, United Kingdom. mark.j.dunne@man.ac.uk
  • Notes:
    DA - 20040112 IS - 0031-9333 LA - eng PT - Journal Article PT - Review RN - 0 (Potassium Channels) RN - 11061-68-0 (Insulin) RN - 50-99-7 (Glucose) SB - IM
Ion channelopathies have now been described in many well-characterized cell types including neurons, myocytes, epithelial cells, and endocrine cells. However, in only a few cases has the relationship between altered ion channel function, cell biology, and clinical disease been defined. Hyperinsulinism in infancy (HI) is a rare, potentially lethal condition of the newborn and early childhood. The causes of HI are varied and numerous, but in almost all cases they share a common target protein, the ATP-sensitive K+ channel. From gene defects in ion channel subunits to defects in beta-cell metabolism and anaplerosis, this review describes the relationship between pathogenesis and clinical medicine. Until recently, HI was generally considered an orphan disease, but as parallel defects in ion channels, enzymes, and metabolic pathways also give rise to diabetes and impaired insulin release, the HI paradigm has wider implications for more common disorders of the endocrine pancreas and the molecular physiology of ion transport
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