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Publication Detail
The measurement of blood flow waveforms from X-ray angiography. Part 1: Principles of the method and preliminary validation
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Brunt JN, Wicks DA, Hawkes DJ, Seifalian AM, du Boulay GH, Colchester AF, Wallis A
  • Publication date:
  • Pagination:
    73, 85
  • Journal:
  • Volume:
  • Issue:
    954-4119 (Print), 2
  • Keywords:
    analysis, Angiography, Biophysics, blood, Blood Flow Velocity, Cineangiography, Computer Simulation, Contrast Media, Image Processing, Computer-Assisted, instrumentation, methods, Models, Cardiovascular, Movement, Pulsatile Flow, Research Support, Non-U.S.Gov't
  • Addresses:
    Department of Medical Biophysics, University of Manchester
  • Notes:
    DA - 19930125
The principles and implementation of a method for measurement of blood flow waveforms from X-ray angiography are described. Contrast medium mass values are obtained at multitudinous positions along individual vessels and from numerous images in a time sequence. These values are represented as a matrix of grey levels in a parametric image. This image is normalized to represent contrast medium concentration, and the movement over time of isoconcentration portions of the contrast bolus is recovered to determine blood flow. Preliminary validation has been undertaken using parametric images generated in two ways: synthesis from a computer model of vascular pulsatile flow and analysis of cine-angiograms of physical models (plastic and perspex tubes) carrying known pulsatile flows. Two distinct methods for interrogation of parametric images by digital image processing were employed; both provided accurate flow measurements
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