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Publication Detail
Validation and clinical application of computer-combined computed tomography and positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose head and neck images
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Wong WL, Hussain K, Chevretton E, Hawkes DJ, Baddeley H, Maisey M, McGurk M
  • Publication date:
  • Pagination:
    628, 632
  • Journal:
  • Volume:
  • Issue:
    002-9610 (Print), 6
  • Print ISSN:
  • Keywords:
    Carcinoma, Squamous Cell, diagnosis, diagnostic use, Female, Fluorine Radioisotopes, Head, Head and Neck Neoplasms, Humans, London, Male, methods, Prospective Studies, radiography, radionuclide imaging, Recurrence, surgery, Tomography, Emission-Computed, Tomography, X-Ray Computed
  • Addresses:
    Department of Oral and Maxillo-Facial Surgery, United Medical School, London, United Kingdom
  • Notes:
    DA - 19970130
BACKGROUND: Positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose (PET-FDG) improves the detection of head and neck squamous cell cancer (HNSCC), but lacks anatomical detail. The accuracy of registered computed tomography/magnetic resonance (CT/MR) and PET-FDG in delineation of HNSCC at the primary site and its clinical application was investigated. METHOD: Preoperatively 30 patients were staged clinically and each had either CT (23), MR (5), or both CT and MR (2) scans, as well as CT/MR-PET-FDG registration. Tumor margins or infiltration of specific anatomical landmarks on the different scans were compared and judged against histology. RESULTS: For primary tumors CT-PET-FDG (97%) and MR-PET-FDG (100%) delineated the tumor more accurately than CT (69%) or MR (40%) alone. Similarly, CT-PET-FDG (98%) and MR-PET-FDG (100%) were better than CT (70%) and MR alone (80%) in identifying tumor invasion of specific anatomical structures. Management was altered in 7 of 30 patients. The registered images were particularly useful in delineating tumor extension in the infratemporal fossa, maxilla and mandible, and identifying recurrences obscured by scar tissue. CONCLUSIONS: It is possible to accurately register CT, MR, and PET-FDG data sets in the head and neck. The initial results show that registered CT/ MR-PET-FDG images provide additional clinically relevant information over that obtained from clinical evaluation or conventional CT/MR imaging
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