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Publication Detail
Current issues and perspectives in hypoplasia of the heart
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Sedmera D, Cook AC, Shirali G, McQuinn TC
  • Publication date:
    01/2005
  • Pagination:
    56, 72
  • Journal:
    Cardiology in the Young
  • Volume:
    15
  • Issue:
    1
  • Status:
    Published
  • Print ISSN:
    1047-9511
  • Language:
    English
  • Keywords:
    Cardiac Morphology, HEART, HYPOPLASIA, Hypoplasia of left heart, prenatal therapy, myocyte proliferation
Abstract
Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.
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