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Publication Detail
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A
  • Publication date:
    06/09/2005
  • Pagination:
    12783, 12788
  • Journal:
    Proc Natl Acad Sci U S A
  • Volume:
    102
  • Issue:
    36
  • Country:
    United States
  • Print ISSN:
    0027-8424
  • PII:
    0506184102
  • Language:
    eng
  • Keywords:
    Androstadienes, Animals, Cell Line, Cell Nucleus, Cercopithecus aethiops, Gene Expression Regulation, Humans, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), Protein Kinase Inhibitors, RNA, Messenger, Rats, Saccharomyces cerevisiae, Transaminases, Transcription, Genetic
Abstract
Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.
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