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Publication Detail
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Saiardi A, Resnick AC, Snowman AM, Wendland B, Snyder SH
  • Publication date:
  • Pagination:
    1911, 1914
  • Journal:
    Proc Natl Acad Sci U S A
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Androstadienes, Caffeine, Cell Death, Fungal Proteins, Inositol Phosphates, Intracellular Signaling Peptides and Proteins, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Telomere
Inositol pyrophosphates physiologically regulate vesicular endocytosis, ribosomal disposition, and directly phosphorylate proteins. Here we demonstrate roles in cell death and regulation of telomere length. Lethal actions of wortmannin and caffeine are selectively abolished in yeast mutants that cannot synthesize inositol pyrophosphates. Wortmannin and caffeine appear to act through the phosphoinositide 3-kinase-related protein kinases Tel1 and Mec1, known regulators of telomere length. Inositol pyrophosphates physiologically antagonize the actions of these kinases, which is demonstrated by the fact that yeast mutants with reduced or elevated levels of inositol pyrophosphates, respectively, display longer and shorter telomeres.
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