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Publication Detail
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Saiardi A, Nagata E, Luo HR, Sawa A, Luo X, Snowman AM, Snyder SH
  • Publication date:
    27/02/2001
  • Pagination:
    2306, 2311
  • Journal:
    Proc Natl Acad Sci U S A
  • Volume:
    98
  • Issue:
    5
  • Country:
    United States
  • Print ISSN:
    0027-8424
  • PII:
    041614598
  • Language:
    eng
  • Keywords:
    Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA Primers, In Situ Hybridization, Inositol 1,4,5-Trisphosphate, Male, Molecular Sequence Data, Phosphotransferases (Alcohol Group Acceptor), Rats, Rats, Sprague-Dawley, Sequence Homology, Amino Acid
Abstract
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additionally, mIPMK forms InsP(4) from Ins(1,4,5)P(3) and InsP(5) from Ins(1,3,4,5)P(4).
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