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Publication Detail
PAX 8 activates the enhancer of the human thyroperoxidase gene.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Esposito C, Miccadei S, Saiardi A, Civitareale D
  • Publication date:
    01/04/1998
  • Pagination:
    37, 40
  • Journal:
    Biochem J
  • Volume:
    331 ( Pt 1)
  • Country:
    ENGLAND
  • Print ISSN:
    0264-6021
  • Language:
    eng
  • Keywords:
    Animals, COS Cells, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Enzymologic, Humans, Nuclear Proteins, Paired Box Transcription Factors, Peroxidases, Rats, Thyroid Gland, Trans-Activators, Transfection
Abstract
In this study we report on a novel natural target of the paired domain transcription factor PAX 8 in the enhancer element of the human thyroperoxidase gene, one of the most important thyroid differentiation markers. It is the primary enzyme involved in thyroid hormone synthesis and PAX 8 has been previously identified as an activating factor of the rat thyroperoxidase gene promoter. In vitro, PAX 8 binds a cis element of the human enhancer and its exogenous expression induces the enhancer activity in co-transfection experiments in Cos-7 cells. When mutated at this binding site, the enhancer is no longer activated by PAX 8. Our finding strengthens the PAX 8 role in the maintenance of thyroid differentiation and in particular in the tissue-specific thyroperoxidase gene expression.
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