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Publication Detail
Cloning and sequence analysis of human thyroid transcription factor 1.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Comparative Study
  • Authors:
    Saiardi A, Tassi V, De Filippis V, Civitareale D
  • Publication date:
    04/04/1995
  • Pagination:
    307, 310
  • Journal:
    Biochim Biophys Acta
  • Volume:
    1261
  • Issue:
    2
  • Country:
    NETHERLANDS
  • Print ISSN:
    0006-3002
  • PII:
    0167-4781(95)00034-E
  • Language:
    eng
  • Keywords:
    Base Sequence, Cell Differentiation, Cloning, Molecular, Gene Expression Regulation, Humans, Iodide Peroxidase, Molecular Sequence Data, Nuclear Proteins, Receptors, Thyrotropin, Sequence Homology, Nucleic Acid, Thyroglobulin, Transcription Factors
Abstract
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype. The authors isolated and analysed the human TTF-1 gene, which shows a striking homology with the rat TTF-1 gene.
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