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Publication Detail
Synergistic transcriptional activation of the thyrotropin receptor promoter by cyclic AMP-responsive-element-binding protein and thyroid transcription factor 1.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Saiardi A, Falasca P, Civitareale D
  • Publication date:
  • Pagination:
    491, 496
  • Journal:
    Biochem J
  • Volume:
    310 ( Pt 2)
  • Status:
  • Country:
  • Print ISSN:
  • Language:
  • Keywords:
    Animals, Base Sequence, Binding Sites, Cell Line, Cell Nucleus, Cercopithecus aethiops, Cyclic AMP Response Element-Binding Protein, Deoxyribonuclease I, Homeodomain Proteins, Kidney, Mutagenesis, Site-Directed, Nuclear Proteins, Promoter Regions, Genetic, Rats, Receptors, Thyrotropin, Recombinant Proteins, Thyroid Gland, Thyroid Nuclear Factor 1, Transcription Factors, Transcriptional Activation, Transfection
In this study we have investigated the molecular mechanisms involved in hormonal induction of thyroid-specific transcription of the thyrotropin receptor (TSHr). A cyclic AMP-responsive element (CRE) has been characterized in the minimal TSHr promoter, and promoter activity shown to be also induced by thyroid transcription factor 1 (TTF-1). We here describe a cooperative effect between TTF-1 and CRE-binding protein on the TSHr promoter. Moreover we have identified a second TTF-1-binding site in the minimal promoter, which does not activate TSHr promoter activity but is required for the co-operative activation of the promoter. This report describes a new aspect of thyroid-specific gene expression, namely, how a generic extracellular signal can be interpreted in a thyroid-specific way.
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