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Publication Detail
The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    McMullan R, Nurrish SJ
  • Publication date:
  • Pagination:
    e17265, ?
  • Journal:
    PLoS One
  • Volume:
  • Issue:
  • Country:
    United States
  • Language:
  • Keywords:
    Age Factors, Aging, Animals, Animals, Genetically Modified, Behavior, Animal, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Fertility, Gagging, Gene Expression Regulation, Heat-Shock Response, Signal Transduction, rho GTP-Binding Proteins, rhoA GTP-Binding Protein
The Rho family of small GTPases are essential during early embryonic development making it difficult to study their functions in adult animals. Using inducible transgenes expressing either a constitutively active version of the single C. elegans Rho ortholog, RHO-1, or an inhibitor of endogenous Rho (C3 transferase), we demonstrate multiple defects caused by altering Rho signaling in adult C. elegans. Changes in RHO-1 signaling in cholinergic neurons affected locomotion, pharyngeal pumping and fecundity. Changes in RHO-1 signaling outside the cholinergic neurons resulted in defective defecation, ovulation, and changes in C. elegans body morphology. Finally both increased and decreased RHO-1 signaling in adults resulted in death within hours. The multiple post-developmental roles for Rho in C. elegans demonstrate that RhoA signaling pathways continue to be used post-developmentally and the resulting phenotypes provide an opportunity to further study post-developmental Rho signaling pathways using genetic screens.
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