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Publication Detail
Multimodality investigation of microstructure: the combination of diffusion NMR and diffuse optical spectroscopy
  • Publication Type:
    Conference
  • Authors:
    Proverbio A, Siow B, Lythgoe M, Gibson A, Alexander D
  • Publisher:
    BMVA
  • Publication date:
    07/2012
  • Place of publication:
    Swansea
  • Pagination:
    87, 92
  • Volume:
    Proceedings of th 16th Conference on Medical Image Understanding and Analysis
  • Name of conference:
    Medical Image Understanding and Analysis 2012
  • Conference place:
    Swansea, UK
  • Conference start date:
    09/07/2012
  • Conference finish date:
    11/07/2012
  • Keywords:
    microstructure, NIR, diffusion NMR, diffuse optical spectroscopy, emulsion
  • Addresses:
    Alessandro Proverbio
    University College London
    Department Medical Physics and Bioengineering
    Malet Place Engineering building, Gower Street
    London
    WC1E 6BT
    United Kingdom
Abstract
We propose that multimodality imaging may be enhanced by combining datasets with a model of the underlying physics prior to image reconstruction, as opposed to the traditional approach of combining the reconstructed image. Here, we demonstrate this approach by merging near infrared diffuse optical spectroscopy with diffusion NMR to inform a model describing the microstructure of sample. A computational validation of the results, produced with synthetic datasets, shows the enhanced accuracy of the estimation, while an application of the model on experimental measurements confirms the validity of the models.
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