Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Effects of phosphate glass fiber-collagen scaffolds on functional recovery of completely transected rat spinal cords
Phosphate-based glass fibers (PGFs), due to characteristics such as biodegradability and directionality, could be effective as spatial cues for axonal outgrowth following nerve injury. In the present study, PGF-containing cylindrical scaffolds of 1.8 mm diameter and 3 mm length were developed and implanted into the gap between the proximal and distal stumps following complete transection of rat spinal cords at T9. The PGF-free collagen scaffolds were implanted into the transected spinal cords of the control group. The open-field Basso, Beattie and Bresnahan locomotor scale revealed that the locomotor function of the experimental group was better than in the control group from 8 to 12 weeks after implantation, and urodynamic analysis revealed additional improvements in the experimental group in some parameters. Twelve weeks after implantation, some axon growth from the proximal and distal stumps to the scaffold was observed in the experimental group but not in the control group. Macrophages surrounded the injured thoracic spinal cord at 1 and 4 weeks after implantation; however, 6 h after implantation, the pro-inflammatory cytokines did not differ between the control and experimental groups. Anterograde corticospinal tract (CST) tracing with biotinylated dextran amine showed that, in the experimental group, some CST outgrowths could reach the lumbar enlargement. By 12 weeks, the mRNA levels of brain-derived neurotrophic factor in the bladder had increased more in the experimental group than in the controls. We conclude that PGFs can have a beneficial effect on functional recovery following complete transection of the thoracic spinal cord in rats. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Biomaterials & Tissue Eng
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by