UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Is myelin a mitochondrion?
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Harris JJ, Attwell D
  • Publication date:
    01/2013
  • Pagination:
    33, 36
  • Journal:
    J Cereb Blood Flow Metab
  • Volume:
    33
  • Issue:
    1
  • Status:
    Published
  • Country:
    United States
  • PII:
    jcbfm2012148
  • Language:
    eng
  • Keywords:
    Adenosine Triphosphate, Energy Metabolism, Extracellular Space, Hydrogen-Ion Concentration, Mitochondria, Mitochondrial Membranes, Mitochondrial Proton-Translocating ATPases, Models, Biological, Myelin Sheath, Oligodendroglia, Protons
Abstract
It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin membrane to synthesize ATP. In fact, if the respiratory chain were present in the myelin membrane, then the ATP synthase would function in reverse, hydrolyzing rather than synthesizing ATP. This calculation places the hypothesis of an energy-producing role for myelin in considerable doubt.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Neuro, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by