UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    MacAskill AF, Little JP, Cassel JM, Carter AG
  • Publication date:
    12/2012
  • Pagination:
    1624, 1626
  • Journal:
    Nat Neurosci
  • Volume:
    15
  • Issue:
    12
  • Status:
    Published
  • Country:
    United States
  • PII:
    nn.3254
  • Language:
    eng
  • Keywords:
    Action Potentials, Animals, Animals, Newborn, Female, Male, Mice, Neural Pathways, Nucleus Accumbens, Organ Culture Techniques, Signal Transduction, Subcellular Fractions
Abstract
We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Neuro, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by