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Publication Detail
Emergence of functional sensory subtypes as defined by transient receptor potential channel expression
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Hjerling-Leffler J, AlQatari M, Ernfors P, Koltzenburg M
  • Publication date:
    07/03/2007
  • Pagination:
    2435, 2443
  • Journal:
    Journal of Neuroscience
  • Volume:
    27
  • Issue:
    10
  • Print ISSN:
    0270-6474
  • Keywords:
    1, A, Acrolein, Adult, Aging, agonists, analogs & derivatives, AND, Animals, Newborn, ARTICLE, Calcium, Calcium Channels, Capsaicin, Cell Differentiation, Cell Lineage, Cells, Cultured, classification, Cold, cytology, development, Embryo, embryology, Embryonic Development, FOR, Ganglia, Spinal, genetics, JOURNAL, Menthol, metabolism, Mice, Inbred C57BL, Neurons, Afferent, Nociceptors, OF, Pain, pharmacokinetics, pharmacology, physiology, Plant Lectins, RNA, Messenger, THE, Thermoreceptors, Transient Receptor Potential Channels, TRPM Cation Channels, TRPV Cation Channels
Abstract
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP) cation channels contributes to this functional heterogeneity. However, little is known about the development of functionally diverse neuronal subpopulations. Here, we use calcium imaging of acutely dissociated mouse sensory neurons and quantitative reverse transcription PCR to show that TRP cation channels emerge in waves, with the diversification of functional groups starting at embryonic day 12.5 (E12.5) and extending well into the postnatal life. Functional responses of voltage-gated calcium channels were present in DRG neurons at E11.5 and reached adult levels by E14.5. Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected. Cold-sensitive neurons were present before the expression or functional responses of TRPM8 or TRPA1. Our data support a lineage relationship in which T
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