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Publication Detail
The enigmatic root cell - emerging roles contributing to fluid homeostasis within the cochlear outer sulcus.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jagger DJ, Forge A
  • Publication date:
    09/2013
  • Pagination:
    1, 11
  • Journal:
    Hear Res
  • Volume:
    303
  • Status:
    Published
  • Country:
    Netherlands
  • PII:
    S0378-5955(12)00252-3
  • Language:
    eng
  • Keywords:
    AC, AE, AQP, ATP, CC, CR, Cc, Cells of Claudius, Claudius' cells, Cx26, Cx30, EP, Hsp27, MEBs, Promentia spiralis, Ps, Sse, Stria vascularis, Sulcus spiralis externus, TRPC, adenosine triphosphate, adenylyl cyclase, anion exchanger, aquaporin, cCx26, canalicular reticulum, canonical transient receptor potential, conditional Cx26, connective tissue gap junction network, connexin26, connexin30, ctgjn, ecgjn, endocochlear potential, epithelial cell gap junction network, heat shock protein-27, marginal cells, mc, membrane-enclosed bodies, oC, ohc, organ of Corti, os, outer hair cell, outer sulcus, rc, root cells, sv, Animals, Cochlea, Connexin 26, Connexins, Endolymph, Gap Junctions, Hearing, Hearing Loss, Homeostasis, Humans, Ion Transport, Perilymph
Abstract
Despite their curious morphology prompting numerous hypotheses of their normal function, the root cells lining the cochlear outer sulcus have long evaded physiological characterization. A growing body of evidence now suggests that they regulate the solute content of the endolymph and/or the perilymph, and may be essential in safe-guarding the global homeostasis of the cochlea. Immuno-labeling experiments have demonstrated polarized expression of key ion transport proteins, and recent electrophysiological recordings have identified specific membrane conductances. These studies have painted a clearer picture of how this unusual cell type may contribute to the maintenance of sound transduction, and how they may be central to pathological processes associated with various forms of hearing loss. This article is part of a Special Issue entitled "Annual Reviews 2013".
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