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Publication Detail
Raman spectroscopy reveals differences in collagen secondary structure which relate to the levels of mineralisation in bones that have evolved for different functions
Abstract
Bone is a compositematerial comprising a collagen fibril scaffold surrounded by crystals of carbonated-hydroxyapatitemineral. It is well established that the relative proportions ofmineral and collagen inmature bone are not definite and are adapted in order to 'tune' its mechanical properties. It is not known, however, how the mineral to collagen ratio is controlled. This paper uses Raman spectroscopy (which permits the probing of both the mineral and the collagen phases of bone) to explore the hypothesis that the control mechanism is related to the nature of the collagen and that bones with different levels of mineralisation have qualitatively different collagen. Raman spectra of functionally adapted bones with varying levels of mineralisation are presented and features that indicate the differences in the collagen's secondary structure (amide I band profiles) and post-translational modification (hydroxyproline/proline ratios) are highlighted. The study demonstrates that Raman spectroscopy can provide a means to investigate the mechanisms that control the mineral to collagen ratio of bone. Understanding these mechanisms could pave the way towards the therapeutic alteration of the mineral to collagen ratio and, thus, the control of the mechanical properties of bone. Copyright © 2012 John Wiley & Sons, Ltd.
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UCL Authors
Inst of Orthopaedics & Musculosk Sci
Inst of Orthopaedics & Musculosk Sci
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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