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Publication Detail
Langerhans Cells Regulate Cutaneous Injury by Licensing CD8 Effector Cells Recruited to the Skin
  • Publication Type:
  • Authors:
    Bennett CL, Fallah-Arani F, Conlan T, Trouillet C, Goold H, Chorro L, Flutter B, Means TK, Geissmann F, Chakraverty R
  • Name of conference:
    International Langerhans Cell Conference
  • Conference place:
    Innsbruk, Austria
  • Conference start date:
  • Conference finish date:
Langerhans cells (LC) are a distinct population of dendritic cells (DC) that form a contiguous network in the epidermis of the skin. Although LC possess many of the properties of highly proficient DC, recent studies have indicated that they are not necessary to initiate cutaneous immunity. In this study, we employed a tractable model of cutaneous graft-versus-host disease (GVHD), induced by topical application of a Toll-like receptor agonist, to explore the role of LC in the development of tissue injury. By adapting this model to permit inducible and selective depletion of host LC, we found that GVHD was significantly reduced when LC were absent. However, LC were not required either for CD8 T-cell activation within the draining lymph node or subsequent homing of effector cells to the epidermis. Instead, we found that LC were necessary for inducing transcription of IFN-γ and other key effector molecules by donor CD8 cells in the epidermis, indicating that they license CD8 cells to induce epithelial injury. These data demonstrate a novel regulatory role for epidermal LC during the effector phase of an inflammatory immune response in the skin.
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