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Publication Detail
MEG Measurement of Cortical Responses to Sound in Guinea Pig and Mouse
  • Publication Type:
  • Authors:
    de Cheveigne A, Chait M, Christianson GB, Robinson B, McAlpine D, Uehara G, Adachi Y, Kawai J, Miyamoto M, Kado H
  • Publication date:
  • Name of conference:
    Annual meeting of the Association for Research in Otolaryngology
  • Conference start date:
Using a newly developed magnetoencephalograph (MEG) for small animals, we have recorded auditory-evoked cortical responses non-invasively in both guinea pig and mouse. The small-animal MEG system has 9 magnetometers placed in an 8x8 mm square array at 3 mm from the outer surface of the liquid helium-filled dewar. An additional set of 3 magnetometers and one accelerometer are used to measure and suppress environmental noise. Sound is delivered either free-field, or via short tubes from Etymotics transducers. Signal processing is crucial to extract the tiny brain responses from noise, and several new techniques have been developed for that purpose. Using these techniques, we can detect cortical responses evoked by sound onsets, transitions and binaural disparities in tone, noise and chirp stimuli, in both guinea pigs and mice. Up to 5 distinct spatio-temporal response components have been observed in these datasets. Additionally, we demonstrate that stimulus-specific adaptation (SSA), hypothesized to be a neural correlate of mismatch negativity (MMN), can be observed in MEG responses to deviant events within trains of standards, and we compare these responses to similar responses observed in humans. These results pave the way for joint MEG and electrophysiology in the same animals to elucidate the neural basis of the MEG response, bridging the gap between human brain imaging and invasive animal electrophysiology. Supported by: Centre National de la Recherche Scientifique, Wellcome Trust, European Union Marie Curie Programme, Kanazawa Institute of Technology, Hokuriku Innovation Cluster for Health Science.
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