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Publication Detail
Adaptation of MEG Responses to Pure Tones in the Guinea Pig
  • Publication Type:
  • Authors:
    Christianson GB, Chait M, de Cheveigne A, Linden J
  • Publication date:
  • Name of conference:
    Annual meeting of the Association for Research in Otolaryngology
  • Conference start date:
Using a newly developed magnetoencephalograph (MEG) for small animals, we have measured cortical responses to onsets and sound transitions in the guinea pig using tone complexes. The small-animal MEG system has 9 magnetometers placed in an 8x8 mm square array. An additional set of 3 magnetometers and one accelerometer are used to measure and suppress environmental noise. Sound is delivered using Etymotics transducers in either closed- or free-field conditions. Auditory onset responses occur with a latency of approximately 50 ms, roughly half that observed in humans, and last 300-400 ms, while offset responses are weak. We have also observed MEG responses consistent with stimulus specific adaptation (SSA). When short pips presented at a regular repetition rate were switched between two frequencies, a greater response was obtained for the first tone following a transition, suggesting that responses to later tones were reduced by adaptation. This effect was significant when the separation between frequencies was greater than an octave. Consistent with previous physiology results, the adaptation was rapid, the response being adapted by the second tone after the transition. The number of tones presented between transitions seems to be a greater determining factor in the adaptation than inter-transition spacing. In the long term, joint MEG and electrophysiology in the same animals will allow us to elucidate the neural basis of the MEG response, bridging the gap between human brain imaging and invasive animal electrophysiology.
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