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Publication Detail
Bridging the gap: Magnetoencephalography in guinea pig reveals rapid auditory cortical adaptation to stimulus statistics
  • Publication Type:
    Conference
  • Authors:
    Linden J, Chait M, de Cheveigne A, Christianson GB
  • Publication date:
    2012
  • Name of conference:
    Society for Neuroscience meeting
  • Conference start date:
    01/01/2012
Abstract
Sensory neural adaptation to stimulus statistics is observed in both humans and animals, but differences in measurement techniques often impede direct comparisons. Here we use small-animal magnetoencephalography (MEG) to show that stimulus-specific adaptation of auditory cortical responses in guinea pig resembles that observed using the same non-invasive neural measurement technique in human studies. We recorded MEG activity in guinea pigs during presentations of repeated tone pips with rare transitions between tone frequencies one octave apart. Tone-evoked MEG waveforms differed between animals, but deflections were consistently observed at 20, 50 and 150 ms latencies. Following tone frequency transitions, the amplitudes of these MEG waves showed rapid adaptation, which appeared to be largely complete after the second tone. The magnitude of adaptation was greater for the guinea pig M50 than for the other waves, and was maximal when inter-tone intervals were short but the number of tones between frequency transitions was large. This pattern of adaptation resembles that observed for the mismatch negativity which occurs in humans following changes in stimulus statistics. We also report more sophisticated forms of adaptation, similar to those observed in humans; for example, guinea pigs show MEG responses to the unexpected omission of the second tone in a tone pair. In the long term, joint MEG and electrophysiology in the same animals will allow us to elucidate the neural basis of auditory MEG responses, bridging the gap between human brain imaging and invasive animal electrophysiology.
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