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Publication Detail
Stimulus-specific adaptation measured in the guinea pig using magnetoencephalography
  • Publication Type:
  • Authors:
    Christianson GB, Chait M, de Cheveigne A, Linden J
  • Publication date:
  • Name of conference:
    International Conference on Auditory Cortex
  • Conference start date:
Using a newly developed magnetoencephalograph (MEG) for small animals, we have measured cortical responses to onsets and sound transitions in guinea pig and gerbil using tone complexes. The small-animal MEG system has 9 magnetometers placed in an 8x8 mm square array. An additional set of 3 magnetometers and one accelerometer are used to measure and suppress environmental noise. Sound is delivered using Etymotics transducers in either closed- or free-field conditions. Using this system, we have characterised some basic properties of sound-evoked MEG responses in rodents. Auditory onset responses occur with a latency of approximately 50 ms and last 300-400 ms, roughly half that observed in humans, while offset responses are extremely weak. We have also observed MEG responses consistent with stimulus-specific adaptation (SSA). When short pips presented at a regular repetition rate were irregularly switched between two frequencies, a greater response was obtained for the first tone following a transition than for later tones. Consistent with previous physiology results, the underlying adaptation was extremely rapid and largely complete by the second pip in a sequence. We also report more sophisticated forms of adaptation, similar to those observed in humans; for example, guinea pigs show MEG responses to the unexpected omission of the second tone in a tone pair. In the long term, joint MEG and electrophysiology in the same animals will allow us to elucidate the neural basis of the MEG response, bridging the gap between human brain imaging and invasive animal electrophysiology.
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