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Publication Detail
Retinal vessel changes after laser treatment for retinopathy of prematurity
  • Publication Type:
    Journal article
  • Publication Sub Type:
    JOUR
  • Authors:
    Kwon JY, Ghodasra DH, Karp KA, Ying GS, Wilson CM, Huang J, Mills MD, Fielder AR, Quinn GE
  • Publication date:
    2012
  • Pagination:
    350, 353
  • Journal:
    J AAPOS
  • Volume:
    16
  • Medium:
    4
  • Print ISSN:
    1528-3933
  • Keywords:
    Arterioles/pathology Female Gestational Age Humans Image Processing, Computer-Assisted Infant, Newborn Infant, Very Low Birth Weight Laser Coagulation Male Pilot Projects Retinal Vessels/ pathology Retinopathy of Prematurity/ surgery Treatment Outcome Venules/pathology
  • Notes:
    Kwon, Julie Y Ghodasra, Devon H Karp, Karen A Ying, Gui-shuang Wilson, Clare M Huang, Jiayan Mills, Monte D Fielder, Alistair R Quinn, Graham E Research Support, Non-U.S. Gov't Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus S1091-8531(12)00218-2 [pii] J AAPOS. 2012 Aug;16(4):350-3. doi: 10.1016/j.jaapos.2012.04.002. Epub 2012 Jul 21. BACKGROUND: The clinical response to retinopathy of prematurity (ROP) treatment is currently assessed subjectively. This study aims to quantify treatment response objectively by assessing changes in digital images of posterior pole retinal vessel width and tortuosity. METHODS: Images of 30 right eyes with type 1 ROP obtained at up to three time points were analyzed: before treatment (T = 0) and 1 (T = 1) and/or 2 weeks (T = 2) after treatment. Width and tortuosity of retinal vessels were analyzed from digital images using computer-assisted image analysis software. RESULTS: Vessel width decreased by 20% (P < 0.004) within the first week and remained stable by the second week after laser treatment. Vessel tortuosity did not significantly change by the first week but decreased 27% (P < 0.01) by second week. CONCLUSIONS: Vessel width appears to decrease dramatic within the first week, whereas the regression of tortuosity follows a slower course.
Abstract
BACKGROUND: The clinical response to retinopathy of prematurity (ROP) treatment is currently assessed subjectively. This study aims to quantify treatment response objectively by assessing changes in digital images of posterior pole retinal vessel width and tortuosity. METHODS: Images of 30 right eyes with type 1 ROP obtained at up to three time points were analyzed: before treatment (T = 0) and 1 (T = 1) and/or 2 weeks (T = 2) after treatment. Width and tortuosity of retinal vessels were analyzed from digital images using computer-assisted image analysis software. RESULTS: Vessel width decreased by 20% (P < 0.004) within the first week and remained stable by the second week after laser treatment. Vessel tortuosity did not significantly change by the first week but decreased 27% (P < 0.01) by second week. CONCLUSIONS: Vessel width appears to decrease dramatic within the first week, whereas the regression of tortuosity follows a slower course.
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