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Publication Detail
Comparison of mesenchymal stem cell proliferation and differentiation between biomimetic and electrochemical coatings on different topographic surfaces
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    García-Gareta E, Hua J, Knowles JC, Blunn GW
  • Publication date:
  • Pagination:
    199, 210
  • Journal:
    Journal of Materials Science: Materials in Medicine
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
The hypothesis for this study was that there is no difference in mesenchymal stem cells (MSCs) proliferation and osteogenic differentiation between calcium-phosphate (CaP) coatings with different crystal size deposited on different topographic surfaces of metal discs. Polished (P) and sand-blasted (SB) tantalum and TiAl6V4 discs were CaP coated by three methods - biomimetic (BioM), electrochemical at 20 mA/cm 2 and at 6.5 mA/cm 2 - and cultured with MSCs. At days 4, 7 and 14, cell proliferation - alamarBlue® activity and DNA quantification - and differentiation down the osteogenic lineage - ALP activity normalised per amount of DNA and SEM (morphology) - were analysed. Results showed that MSCs proliferated more when cultured on the nano-sized BioM coatings compared to uncoated and electrochemically coated discs. MSCs also proliferated more on P surfaces than on SB and or electrochemical coatings. All the coatings induced osteogenic differentiation, which was greater on electrochemical coatings and SB discs. © 2012 Springer Science+Business Media New York.
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