UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
In-vitro characterisation of terbutaline sulphate particles prepared by thermal ink-jet spray freeze drying
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Sharma G, Mueannoom W, Buanz ABM, Taylor KMG, Gaisford S
  • Publisher:
    Elsevier
  • Publication date:
    2013
  • Pagination:
    165, 170
  • Journal:
    International Journal of Pharmaceutics
  • Volume:
    447
  • Keywords:
    Ink-jet printing, Terbutaline sulphate, Spray freeze drying, Inhalation
  • Addresses:
    UCL School of Pharmacy
    Pharmaceutics
    29-39 Brunswick Square
    London
    WC1N 1AX
    UK
Abstract
Thermal ink-jet spray freeze-drying (TIJ-SFD) was used to produce inhalable particles of terbutaline sulphate, the aerosolisation properties of which were compared to the commercial Bricanyl® formulation. Scanning electron micrograph images showed the particles to be spherical, highly porous and suitable for aerosolisation from a simple, capsule-based dry-powder device (Cyclohaler®) without the need for additional excipients. Particle size was dependent upon the concentration of solution jetted, as well as the distance between the print head and the surface of the liquid nitrogen. Starting with a 5% w/v solution and maintaining this distance at 3 cm produced spherical, porous particles of volume median diameter 14.1 ± 0.8 μm and mass median aerodynamic diameter (MMAD) 4.0 ± 0.6 μm. The fine particle fraction (proportion of aerosol with MMAD ≤ 4.46 μm) was 22.9 ± 3.3%, which compared favourably with that of the marketed dry powder inhaler formulation of terbutaline (Bricanyl® Turbohaler®; 25.7 ± 3.8%), tested under the same conditions. These findings show that TIJ-SFD is a useful tool to predict the viability of a DPI formulation during preformulation physicochemical characterisation.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Pharmaceutics
Author
UCL School of Pharmacy
Author
Pharmaceutics
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by