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Publication Detail
In-vitro characterisation of terbutaline sulphate particles prepared by thermal ink-jet spray freeze drying
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Sharma G, Mueannoom W, Buanz ABM, Taylor KMG, Gaisford S
  • Publisher:
  • Publication date:
  • Pagination:
    165, 170
  • Journal:
    International Journal of Pharmaceutics
  • Volume:
  • Keywords:
    Ink-jet printing, Terbutaline sulphate, Spray freeze drying, Inhalation
  • Addresses:
    UCL School of Pharmacy
    29-39 Brunswick Square
    WC1N 1AX
Thermal ink-jet spray freeze-drying (TIJ-SFD) was used to produce inhalable particles of terbutaline sulphate, the aerosolisation properties of which were compared to the commercial Bricanyl® formulation. Scanning electron micrograph images showed the particles to be spherical, highly porous and suitable for aerosolisation from a simple, capsule-based dry-powder device (Cyclohaler®) without the need for additional excipients. Particle size was dependent upon the concentration of solution jetted, as well as the distance between the print head and the surface of the liquid nitrogen. Starting with a 5% w/v solution and maintaining this distance at 3 cm produced spherical, porous particles of volume median diameter 14.1 ± 0.8 μm and mass median aerodynamic diameter (MMAD) 4.0 ± 0.6 μm. The fine particle fraction (proportion of aerosol with MMAD ≤ 4.46 μm) was 22.9 ± 3.3%, which compared favourably with that of the marketed dry powder inhaler formulation of terbutaline (Bricanyl® Turbohaler®; 25.7 ± 3.8%), tested under the same conditions. These findings show that TIJ-SFD is a useful tool to predict the viability of a DPI formulation during preformulation physicochemical characterisation.
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