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Publication Detail
Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex
Abstract
During voluntary action, dorsal premotor cortex (PMd) may exert influences on motor regions in both hemispheres, but such inter-regional interplay is not well understood. We used transcranial magnetic stimulation (TMS) concurrently with event-related functional magnetic resonance imaging to study such interplay directly. We tested whether causal influences from left PMd upon contralateral (right) motor areas depends on the current state of the motor system, involving regions engaged in a current task. We applied short bursts (360 ms) of high or low intensity TMS to left PMd, during single isometric left-hand grips or during rest. TMS to left PMd affected activity in contralateral right PMd and primary motor cortex (M1), in a state-dependent manner. During active left-hand grip, high (vs low) intensity TMS led to activity increases in contralateral right PMd and M1, whereas activity decreases there due to TMS were observed instead during no-grip rest. Analyses of condition-dependent functional coupling confirmed topographically-specific stronger coupling between left PMd with right PMd (and right M1) when high intensity TMS was applied to left PMd during left-hand grip. We conclude that left PMd can exert state-dependent interhemispheric influences on contralateral cortical motor areas relevant for a current motor task.
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Clinical and Movement Neurosciences
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Institute of Cognitive Neuroscience
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Clinical and Movement Neurosciences
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Clinical and Movement Neurosciences
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Imaging Neuroscience
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