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Publication Detail
High strength re-mineralizing, antibacterial dental composites with reactive calcium phosphates.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Mehdawi IM, Pratten J, Spratt DA, Knowles JC, Young AM
  • Publication date:
  • Pagination:
    473, 484
  • Journal:
    Dent Mater
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Actinomyces, Anti-Bacterial Agents, Calcium Phosphates, Carbon Compounds, Inorganic, Cells, Cultured, Chlorhexidine, Composite Resins, Compressive Strength, Lactobacillus casei, Methacrylates, Nanoparticles, Silicon Compounds, Spectroscopy, Fourier Transform Infrared, Streptococcus mutans, X-Ray Diffraction
OBJECTIVE: Development of high strength dental composites with adhesive, antibacterial and re-mineralizing potential. MATERIALS: Urethane and triethylene glycol dimethacrylates were combined with HEMA (10 or 20wt%) and 2MP (2 or 10wt%), antibacterial chlorhexidine (2.5wt%) and chemical cure initiators. Reactive mono/tri calcium phosphate (CP) mixed with silica/silicon carbide nanoparticles (S) (CP:S weight ratio 1:2 or 2:1) was added (50wt%). RESULTS: Decreasing CP/S ratio and HEMA content reduced monomer conversion at 15min from 93 to 63%. Conversely, decreasing CP/S increased initial "dry" compressive (137-203MPa) and flexural (79-116MPa) strength. With high HEMA content, these decreased by ∼15-20MPa upon 24h water storage. With low HEMA content, average decline was <8MPa due to reduced water sorption. Early water sorption induced mass increase, volume expansion, mono calcium phosphate dissolution and chlorhexidine release, were proportional to the initial calcium phosphate content. Furthermore, they increased ∼1.5 fold upon raising HEMA wt%. These diffusion controlled processes and strength decline slowed after 24h as phosphates reaction bound water within the materials. Increasing 2MP concentration reduced calcium release but did not affect strength. Formulations with high CP/S indicated greater antibacterial activity in agar diffusion and in vitro biofilm tests. SIGNIFICANCE: New material use beneath a conventional composite could potentially reduce high failure rates associated with residual caries and bacterial microleakage.
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