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Publication Detail
Titanium phosphate glass microspheres for bone tissue engineering.
  • Publication Type:
    Journal article
  • Authors:
    Lakhkar NJ, Park JH, Mordan NJ, Salih V, Wall IB, Kim HW, King SP, Hanna JV, Martin RA, Addison O, Mosselmans JF, Knowles JC
  • Publication date:
    11/2012
  • Pagination:
    4181, 4190
  • Journal:
    Acta biomaterialia
  • Volume:
    8
  • Issue:
    11
Abstract
We have demonstrated the successful production of titanium phosphate glass microspheres in the size range of ∼10-200 μm using an inexpensive, efficient, easily scalable process and assessed their use in bone tissue engineering applications. Glasses of the following compositions were prepared by melt-quench techniques: 0.5PO-0.4CaO-(0.1-x)NaO-xTiO, where x=0.03, 0.05 and 0.07 mol fraction (denoted as Ti3, Ti5 and Ti7 respectively). Several characterization studies such as differential thermal analysis, degradation (performed using a novel time lapse imaging technique) and pH and ion release measurements revealed significant densification of the glass structure with increased incorporation of TiO in the glass from 3 to 5 mol.%, although further TiO incorporation up to 7 mol.% did not affect the glass structure to the same extent. Cell culture studies performed using MG63 cells over a 7-day period clearly showed the ability of the microspheres to provide a stable surface for cell attachment, growth and proliferation. Taken together, the results confirm that 5 mol.% TiO glass microspheres, on account of their relative ease of preparation and favourable biocompatibility, are worthy candidates for use as substrate materials in bone tissue engineering applications. Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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Biomaterials & Tissue Eng
Dept of Biochemical Engineering
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