UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Electrohydrodynamic bubbling: an alternative route to fabricate porous structures of silk fibroin based materials.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Ekemen Z, Ahmad Z, Stride E, Kaplan D, Edirisinghe M
  • Publication date:
    13/05/2013
  • Pagination:
    1412, 1422
  • Journal:
    Biomacromolecules
  • Volume:
    14
  • Issue:
    5
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    Animals, Biomimetic Materials, Bombyx, Electrochemical Techniques, Fibroins, Hydrodynamics, Materials Testing, Microbubbles, Microtechnology, Porosity, Protein Structure, Secondary, Surface Properties, Tensile Strength, Tissue Engineering, Tissue Scaffolds
Abstract
Conventional fabrication techniques and structures employed in the design of silk fibroin (SF) based porous materials provide only limited control over pore size and require several processing stages. In this study, it is shown that, by utilizing electrohydrodynamic bubbling, not only can new hollow spherical structures of SF be formed in a single step by means of bubbles, but the resulting bubbles can serve as pore generators when dehydrated. The bubble characteristics can be controlled through simple adjustments to the processing parameters. Bubbles with diameters in the range of 240-1000 μm were fabricated in controlled fashion. FT-IR characterization confirmed that the rate of air infused during processing enhanced β-sheet packing in SF at higher flow rates. Dynamic mechanical analysis also demonstrated a correlation between air flow rate and film tensile strength. Results indicate that electrohydrodynamically generated SF and their composite bubbles can be employed as new tools to generate porous structures in a controlled manner with a range of potential applications in biocoatings and tissue engineering scaffolds.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
Dept of Mechanical Engineering
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by