UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Sticking together the Crumbs - an unexpected function for an old friend.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Research Support, Non-U.S. Gov't
  • Authors:
    Thompson BJ, Pichaud F, Röper K
  • Publication date:
    05/2013
  • Pagination:
    307, 314
  • Journal:
    Nat Rev Mol Cell Biol
  • Volume:
    14
  • Issue:
    5
  • Status:
    Published
  • Country:
    England
  • PII:
    nrm3568
  • Language:
    eng
  • Keywords:
    Animals, Cell Communication, Cell Polarity, Epithelial Cells, Humans, Intercellular Junctions, Membrane Proteins, Nerve Tissue Proteins
Abstract
Cell polarity and cell-cell junctions have pivotal roles in organizing cells into tissues and in mediating cell-cell communication. The transmembrane protein Crumbs has a well-established role in the maintenance of epithelial polarity, and it can also regulate signalling via the Notch and Hippo pathways to influence tissue growth. The functions of Crumbs in epithelial polarity and Hippo-mediated growth depend on its short intracellular domain. Recent evidence now points to a conserved and fundamental role for the extracellular domain of Crumbs in mediating homophilic Crumbs-Crumbs interactions at cell-cell junctions.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Lab for Molecular Cell Bio MRC-UCL
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by