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Publication Detail
The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jeyabalan J, Viollet B, Smitham P, Ellis SA, Zaman G, Bardin C, Goodship A, Roux JP, Pierre M, Chenu C
  • Publication date:
  • Pagination:
    2659, 2670
  • Journal:
    Osteoporos Int
  • Volume:
  • Issue:
  • Country:
  • Language:
  • Keywords:
    AMP-Activated Protein Kinases, Animals, Bone Density, Bone Remodeling, Bony Callus, Enzyme Activation, Female, Femoral Fractures, Femur, Fracture Healing, Hypoglycemic Agents, Metformin, Mice, Mice, Inbred C57BL, Osteoporosis, Ovariectomy, Rats, Rats, Wistar, Tibia, X-Ray Microtomography
The present study shows no adverse effects of the anti-diabetic drug metformin on bone mass and fracture healing in rodents but demonstrates that metformin is not osteogenic in vivo, as previously proposed.
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Dept of Med Phys & Biomedical Eng
Inst of Orthopaedics & Musculosk Sci
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