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Publication Detail
Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Schneider SA, Wilkinson L, Bhatia KP, Henley SMD, Rothwell JC, Tabrizi SJ, Jahanshahi M
  • Publication date:
  • Pagination:
    1343, 1349
  • Journal:
    Mov Disord
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Language:
  • Keywords:
    Adult, Age of Onset, Executive Function, Female, Humans, Huntington Disease, Learning Disabilities, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Serial Learning, Statistics as Topic, Trinucleotide Repeat Expansion
Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.
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Clinical and Movement Neurosciences
UCL Queen Square Institute of Neurology
Clinical and Movement Neurosciences
Neurodegenerative Diseases
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