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Publication Detail
Development of a novel bioactive prosthesis based on an advanced surface modified nanocomposite material and circulating progenitor stem cells
  • Publication Type:
  • Authors:
    Ghanbari H, Rahmani B, Burriesci G, Seifalian AM
  • Publisher:
    INST Sharif University of Technology
  • Publication date:
  • Pagination:
    713, 714
  • Published proceedings:
    Proceedings of the 4th International Conference on Nanostructures (ICNS4)
  • Name of conference:
    4th International Conference on Nanostructures (ICNS4)
  • Conference place:
    Kish Island, Iran
  • Conference start date:
  • Conference finish date:
  • Keywords:
    nanocomposite, polyhedral oligomeric silsesquioxane, heart valve, endothelial progenitor cells (EPC), bioactive
A novel heart valve prosthesis was designed and fabricated using an advanced nanocomposite material based on polyhedral oligomeric silsesquioxane (POSS) nanoparticle and polycarbonate ureaurethane (PCU). The valve material was characterised for mechanical and surface properties and was tested under physiological pulsatile flow conditions for calcification properties. The surface of the leaflets was further functionalised using bioactive peptides to enhance in-site endothelialisation potential. Circulating endothelial progenitor stem cells (EPCs) were isolated and the valves were incubated in bioreactor to study EPCs attachment and growth. The valves were also tested for hydrodynamic performance using a pulse-duplicator system. The results revealed improved mechanical and surface properties and significant resistance to calcification. EPC static culture showed excellent cell viability, clonal expansion and differentiation of EPCs to the endothelial cells after 3 weeks culture on the valve leaflets. Dynamic EPC culture on bioreactor proved the concept of cell attachment under simulated physiological pulsatile flow conditions. The valve revealed enhanced hydrodynamic performance compared to the controls in the pulse-duplicator system. The results indicate that this novel valve prototype can be considered as a breakthrough in the development of next generation bioactive valves with enhanced functional properties and in-situ endothelialisation potential.
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