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Publication Detail
Design and development of nanocomposite scaffolds for auricular reconstruction.
Abstract
Auricular reconstruction using sculpted autologous costal cartilage is effective, but complex, time consuming and may incur donor site sequelae and morbidity. Conventional synthetic alternatives are associated with infection and extrusion in up to 15% of cases. We present a novel POSS-PCU nanocomposite auricular scaffold, which aims to reduce extrusion rates by mimicking the elastic modulus of human ears and by encouraging desirable cellular interactions. The fabrication, physicochemical properties (including nanoscale topography) and cellular interactions of these scaffolds were compared to Medpor®, the current synthetic standard. Our scaffold had a more similar elastic modulus (5.73± 0.17 MPa) to ear cartilage (5.02± 0.17 MPa) compared with Medpor®, which was much stiffer (140.9±0.04 MPa). POSS-PCU supported fibroblast ingrowth and proliferation, significantly higher collagen production was also produced by cells on the POSS-PCU than those on Medpor®. This porous POSS-PCU nanocomposite scaffold is therefore a promising alternative biomaterial for auricular surgical reconstruction.
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Research Department of General Surgery
Research Department of General Surgery
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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