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Publication Detail
Light-induced generation of singlet oxygen by naked gold nanoparticles and its implications to cancer cell phototherapy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Pasparakis G
  • Publication date:
    20/12/2013
  • Pagination:
    4130, 4134
  • Journal:
    Small
  • Volume:
    9
  • Issue:
    24
  • Status:
    Published
  • Country:
    Germany
  • Language:
    eng
  • Keywords:
    cancer, gold nanoparticles, lasers, photothermal therapy, plasmons, singlet oxygen, Cell Line, Tumor, Electrons, Gold, HeLa Cells, Humans, Metal Nanoparticles, Nanotechnology, Neoplasms, Oxygen, Photochemistry, Phototherapy, Reactive Oxygen Species, Singlet Oxygen, Surface Plasmon Resonance, Temperature
Abstract
Generation of singlet oxygen by direct irradiation of naked gold nanoparticles is observed using either continuous wave or pulsed laser sources. The underlying mechanism involves plasmon- and hot-electron-mediated reaction pathways and (1) O2 seems to significantly amplify the overall death rates during photothermal treatment of cancer cell lines in vitro.
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