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Publication Detail
TRACT-ORIENTED STATISTICAL GROUP COMPARISON OF DIFFUSION IN SHEET-LIKE WHITE MATTER
  • Publication Type:
    Conference
  • Authors:
    Lyksborg M, Dyrby TB, Sorensen PS, Blinkenberg M, Siebner HR, Alexander D, Larsen R, Zhang H
  • Publication date:
    04/2013
  • Name of conference:
    IEEE International Symposium on Biomedical Imaging: From Nano to Macro
  • Conference place:
    San Francisco, California, USA
  • Conference start date:
    07/04/2013
  • Conference finish date:
    11/04/2013
Abstract
Identifying specific structures of the brain where pathology differs between groups of subjects may aid to develop imaging-based markers for disease diagnosis. We propose a new technique for doing multivariate statistical analysis on white matter tracts with sheet like shapes. Previous works assume tube-like shapes, not always suitable for modelling the white matter tracts of the brain. The tract-oriented technique aimed at group studies, integrates the usage of multivariate features and outputs a single value of significance indicating tract-specific differences. This is in contrast to voxel based analysis techniques which outputs a significance per voxel basis, and requires multiple comparison correction. We demonstrate our technique by comparing a group of controls with a group of Multiple Sclerosis subjects obtaining significant differences on 11 different fascicle structures.
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