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Publication Detail
Silk fibroin-polyurethane blends: physical properties and effect of silk fibroin content on viscoelasticity, biocompatibility and myoblast differentiation.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Park H-S, Gong M-S, Park J-H, Moon S-I, Wall IB, Kim H-W, Lee JH, Knowles JC
  • Publication date:
  • Pagination:
    8962, 8971
  • Journal:
    Acta Biomater
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Biocompatibility, Myogenesis, Polyurethane, Silk, Viscoelasticity, Animals, Biocompatible Materials, Cell Adhesion, Cell Count, Cell Differentiation, Cell Line, Cell Proliferation, Cell Shape, Elastic Modulus, Elasticity, Fibroins, Fluorescent Antibody Technique, Focal Adhesion Protein-Tyrosine Kinases, Gene Expression Regulation, Materials Testing, Membranes, Artificial, Mice, Muscle Development, Myoblasts, Polyurethanes, RNA, Messenger, Spectroscopy, Fourier Transform Infrared, Surface Properties, Tensile Strength, Thermogravimetry, Viscosity
As a way to modify both the physical and biological properties of a highly elastic and degradable polyurethane (PU), silk fibroin (SF) was blended with the PU at differing ratios. With increasing SF content, the tensile strength decreased as did the strain at break; the stiffness increased to around 35 MPa for the highest silk content. C2C12 (a mouse myoblast cell line) cells were used for in vitro experiments and showed significantly improved cell responses with increasing SF content. With increasing SF content the number of non-adherent cells was reduced at both 4 and 8h compared to the sample with the lowest SF content. In addition, muscle marker genes were upregulated compared to the sample containing no SF, and in particular sarcomeric actin and α-actin.
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