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Publication Detail
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    JOUR
  • Authors:
    Ripke S Fau - O'Dushlaine C, O'Dushlaine C Fau - Chambert K, Chambert K Fau - Moran JL, Moran Jl Fau - Kahler AK, Kahler Ak Fau - Akterin S, Akterin S Fau - Bergen SE, Bergen Se Fau - Collins AL, Collins Al Fau - Crowley JJ, Crowley Jj Fau - Fromer M, Fromer M Fau - Kim Y, Kim Y Fau - Lee SH, Lee Sh Fau - Magnusson PKE, Magnusson Pk Fau - Sanchez N, Sanchez N Fau - Stahl EA, Stahl Ea Fau - Williams S, Williams S Fau - Wray NR, Wray Nr Fau - Xia K, Xia K Fau - Bettella F, Bettella F Fau - Borglum AD, Borglum Ad Fau - Bulik-Sullivan BK, Bulik-Sullivan Bk Fau - Cormican P, Cormican P Fau - Craddock N, Craddock N Fau - de Leeuw C, de Leeuw C Fau - Durmishi N, Durmishi N Fau - Gill M, Gill M Fau - Golimbet V, Golimbet V Fau - Hamshere ML, Hamshere Ml Fau - Holmans P, Holmans P Fau - Hougaard DM, Hougaard Dm Fau - Kendler KS, Kendler Ks Fau - Lin K, Lin K Fau - Morris DW, Morris Dw Fau - Mors O, Mors O Fau - Mortensen PB, Mortensen Pb Fau - Neale BM, Neale Bm Fau - O'Neill FA, O'Neill Fa Fau - Owen MJ, Owen Mj Fau - Milovancevic MP, Milovancevic Mp Fau - Posthuma D, Posthuma D Fau - Powell J, Powell J Fau - Richards AL, Richards Al Fau - Riley BP, Riley Bp Fau - Ruderfer D, Ruderfer D Fau - Rujescu D, Rujescu D Fau - Sigurdsson E, Sigurdsson E Fau - Silagadze T, Silagadze T Fau - Smit AB, Smit Ab Fau - Stefansson H, Stefansson H Fau - Steinberg S, Steinberg S Fau - Suvisaari J, Suvisaari J Fau - Tosato S, Tosato S Fau - Verhage M, Verhage M Fau - Walters JT, Walters JT, Levinson Df Fau - Gejman PV, Gejman Pv Fau - Kendler KS, Kendler Ks Fau - Laurent C, Laurent C Fau - Mowry BJ, Mowry Bj Fau - O'Donovan MC, O'Donovan Mc Fau - Owen MJ, Owen Mj Fau - Pulver AE, Pulver Ae Fau - Riley BP, Riley Bp Fau - Schwab SG, Schwab Sg Fau - Wildenauer DB, Wildenauer Db Fau - Dudbridge F, Dudbridge F Fau - Holmans P, Holmans P Fau - Shi J, Shi J Fau - Albus M, Albus M Fau - Alexander M, Alexander M Fau - Campion D, Campion D Fau - Cohen D, Cohen D Fau - Dikeos D, Dikeos D Fau - Duan J, Duan J Fau - Eichhammer P, Eichhammer P Fau - Godard S, Godard S Fau - Hansen M, Hansen M Fau - Lerer FB, Lerer Fb Fau - Liang K, Liang Ky Fau - Maier W, Maier W Fau - Mallet J, Mallet J Fau - Nertney DA, Nertney Da Fau - Nestadt G, Nestadt G Fau - Norton N, Norton N Fau - O'Neill FA, O'Neill Fa Fau - Papadimitriou GN, Papadimitriou Gn Fau - Ribble R, Ribble R Fau - Sanders AR, Sanders Ar Fau - Silverman JM, Silverman Jm Fau - Walsh D, Walsh D Fau - Williams NM, Williams Nm Fau - Wormley B, Wormley B, Arranz Mj Fau - Bakker S, Bakker S Fau - Bender S, Bender S Fau - Bramon E, Bramon E Fau - Collier D, Collier D Fau - Crespo-Facorro B, Crespo-Facorro B Fau - Hall J, Hall J Fau - Iyegbe C, Iyegbe C Fau - Jablensky A
  • Publication date:
    2013
  • Journal:
    Nature Genetics
  • Volume:
    Ahead of Publication
  • Medium:
    1546-1718 (Electronic)
  • Notes:
    Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
Abstract
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
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Division of Psychiatry
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Clinical Epidemiology
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Genetics, Evolution & Environment
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Clinical and Movement Neurosciences
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