Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Hayward AC, Wang L, Goonetilleke N, Fragaszy E, Bermingham A, Copas A, Millett E, Nazareth I, Nguyen-Van-Tam J, Watson J, Zambon M, Johnson A, McMichael A
  • Publisher:
    American Thoracic Society
  • Publication date:
  • Pagination:
    1422, 1431
  • Journal:
    American Journal of Respiratory and Critical Care Medicine
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
We aimed to determine whether T cells contribute to influenza immunity. In a cohort of 1703 unvaccinated volunteers we quantified influenza (H3N2 virus) specific T cells before the 2006/7, 2007/8 and 2008/9 epidemic seasons and the 2009 pandemic. Follow up used serology, symptom reporting and PCR based viral investigation of symptomatic cases. Pre-season T cell memory was low, but detectable, in most participants. T cell responses to nucleoprotein dominated and in those infected with influenza (based on a 4 fold antibody titre rise) protected against PCR confirmed influenza (adjusted odds ratio 0.27 (0.11-0.68) p=0.005, during pandemic (p=0.047) and seasonal periods (p=0.049), and against respiratory illness in those infected with pandemic influenza (adjusted incidence rate ratio 0.31 (0.11-0.82) p=0.018). Protection was independent of baseline antibodies. In those who became ill NP-specific T cell responses did not alter duration or severity of symptoms.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Epidemiology & Public Health
Infection & Population Health
Primary Care & Population Health
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by