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Publication Detail
Feasibility of multimodal 3D neuroimaging to guide implantation of intracranial EEG electrodes.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Rodionov R, Vollmar C, Nowell M, Miserocchi A, Wehner T, Micallef C, Zombori G, Ourselin S, Diehl B, McEvoy AW, Duncan JS
  • Publication date:
    11/2013
  • Pagination:
    91, 100
  • Journal:
    Epilepsy Res
  • Volume:
    107
  • Issue:
    1-2
  • Status:
    Published
  • Country:
    Netherlands
  • PII:
    S0920-1211(13)00196-4
  • Language:
    eng
  • Keywords:
    Epilepsy, Multimodal, Neuroimaging, Surgery, Adult, Brain, Electrodes, Implanted, Electroencephalography, Feasibility Studies, Female, Humans, Male, Multimodal Imaging, Neuroimaging, Neuronavigation, Seizures
Abstract
BACKGROUND: Since intracranial electrode implantation has limited spatial sampling and carries significant risk, placement has to be effective and efficient. Structural and functional imaging of several different modalities contributes to localising the seizure onset zone (SoZ) and eloquent cortex. There is a need to summarise and present this information throughout the pre/intra/post-surgical course. METHODS: We developed and implemented a multimodal 3D neuroimaging (M3N) pipeline to guide implantation of intracranial EEG (icEEG) electrodes. We report the implementation of the pipeline for operative planning and a description of its use in clinical decision-making. RESULTS: The results of intraoperative application of the M3N pipeline demonstrated clinical benefits in all 15 implantation surgeries assessed. The M3N software was used to simulate placement of intracranial electrodes in 2 cases. The key benefits of using the M3N pipeline are illustrated in 3 representative case reports. CONCLUSION: We have demonstrated feasibility of the developed intraoperative M3N pipeline which serves as a prototype for clinical implementation. Further validity studies with larger sample groups are required to determine the utility of M3N in routine surgical practice.
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Clinical & Experimental Epilepsy
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Clinical & Experimental Epilepsy
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Dept of Med Phys & Biomedical Eng
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Clinical & Experimental Epilepsy
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