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Publication Detail
A new technique for the assessment of the 3D spatial distribution of the Calcium/Phosphorus ratio in bone apatite
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Hadjipanteli A, Kourkoumelis N, Fromme P, Olivo A, Huang J, Speller R
  • Publication date:
    01/10/2013
  • Pagination:
    1399, 1410
  • Journal:
    Physiological Measurement
  • Volume:
    34
  • Issue:
    11
  • Addresses:
    UCL
Abstract
The value and distribution of Calcium/Phosphorus (Ca/P) ratio in bone vary between healthy and osteoporotic bone. The purpose of this study was the development of a technique for the assessment of the 3D spatial distribution of Ca/P ratio in bone apatite, which could eventually be implemented through a conventional computed tomography (CT) system. A three-material mass-fraction decomposition CT dual energy analysis was optimised. The technique was validated using ten bone phantoms of different, known Ca/P ratio. Their measured average Ca/P ratio showed a mean/maximum deviation from the expected Ca/P ratio of 0.24/0.35. Additionally, three healthy and three inflammation-mediated osteoporotic (IMO) collagen-free rabbit tibia bone samples were assessed, providing promising preliminary results on real bone tissue. The average Ca/P ratios in all IMO samples (1.64-1.65) were found to be lower than in healthy samples (1.67-1.68). Osteoporotic regions in IMO samples were located using Ca/P ratio colour maps and Ca/P ratio values as low as 1.40±0.26 were found. The low Ca/P ratio volume proportion in IMO samples (12.8%-13.9%) was found to be higher than in healthy (5.8%-8.3%) samples. A region growing technique showed a higher homogeneity of Ca/P ratio in healthy than in IMO bone samples.
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