Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Sadnicka A, Kimmich O, Pisarek C, Ruge D, Galea J, Kassavetis P, Pareés I, Saifee T, Molloy A, Bradley D, O'Riordan S, Zrinzo L, Hariz M, Bhatia KP, Limousin P, Foltynie T, Rothwell JC, Hutchinson M, Edwards MJ
  • Publication date:
  • Pagination:
    1874, 1877
  • Journal:
    Movement Disorders
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
Background: We investigated whether clinical improvement observed after deep brain stimulation (DBS) of the globus pallidus internus (GPi) in cervical dystonia (CD) is paralleled by the normalisation of temporal discrimination thresholds (TDTs), a marker of abnormal sensory processing in CD. Methods: TDT was tested in 11 patients with CD after they received DBS and was compared with TDT scores from 24 patients with CD and a group of 61 controls. Results: A clear clinical response to GPi-DBS was demonstrated (total Toronto Western Spasmodic Torticollis Rating Scale scores fell from 50 to 18; P<0.001). In contrast, TDT remained abnormal in the CD-DBS group (P<0.001) and was not significantly different from the abnormal TDT range observed in CD. Conclusions: Underlying sensory abnormalities in temporal discrimination observed in dystonia do not seem to be corrected by successful GPi-DBS. This adds further data to the ongoing debate regarding which pathophysiological abnormalities observed in dystonia are likely to be causal in the genesis of the disease rather than epiphenomena observed secondary to abnormal motor activity. © 2013 Movement Disorder Society.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers Show More
Clinical and Movement Neurosciences
Clinical and Movement Neurosciences
Department of Neuromuscular Diseases
Clinical and Movement Neurosciences
Clinical and Movement Neurosciences
Clinical and Movement Neurosciences
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by