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Publication Detail
Coherent x-ray imaging of collagen fibril distributions within intact tendons.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Berenguer F, Bean RJ, Bozec L, Vila-Comamala J, Zhang F, Kewish CM, Bunk O, Rodenburg JM, Robinson IK
  • Publication date:
    21/01/2014
  • Pagination:
    459, 466
  • Journal:
    Biophys J
  • Volume:
    106
  • Issue:
    2
  • Status:
    Published
  • Country:
    United States
  • PII:
    S0006-3495(13)05806-2
  • Language:
    eng
  • Keywords:
    Algorithms, Animals, Fibrillar Collagens, Image Processing, Computer-Assisted, Molecular Imaging, Rats, Tendons, X-Ray Diffraction, X-Rays
Abstract
The characterization of the structure of highly hierarchical biosamples such as collagen-based tissues at the scale of tens of nanometers is essential to correlate the tissue structure with its growth processes. Coherent x-ray Bragg ptychography is an innovative imaging technique that gives high resolution images of the ordered parts of such samples. Herein, we report how we used this method to image the collagen fibrillar ultrastructure of intact rat tail tendons. The images show ordered fibrils extending over 10-20 μm in length, with a quantifiable D-banding spacing variation of 0.2%. Occasional defects in the fibrils distribution have also been observed, likely indicating fibrillar fusion events.
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